Monday, April 29, 2013

Spurs finish 4-game sweep, routing Lakers 103-82

San Antonio Spurs forward Tim Duncan (21) pats guard Tony Parker (9), of France, on the head after he scored as Los Angeles Lakers center Dwight Howard (12) faces away during the first half in Game 4 of a first-round NBA basketball playoff series, Sunday, April 28, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

San Antonio Spurs forward Tim Duncan (21) pats guard Tony Parker (9), of France, on the head after he scored as Los Angeles Lakers center Dwight Howard (12) faces away during the first half in Game 4 of a first-round NBA basketball playoff series, Sunday, April 28, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Los Angeles Lakers center Dwight Howard, right, shoots as San Antonio Spurs forward Tim Duncan defends during the first half in Game 4 of a first-round NBA basketball playoff series, Sunday, April 28, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

Los Angeles Lakers forward Pau Gasol, right, of Spain, shoots as San Antonio Spurs forward Matt Bonner defends during the first half in Game 4 of a first-round NBA basketball playoff series, Sunday, April 28, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

San Antonio Spurs guard Danny Green (4) grabs a rebound away from Los Angeles Lakers guard Darius Morris during the first half in Game 4 of a first-round NBA basketball playoff series, Sunday, April 28, 2013, in Los Angeles. (AP Photo/Mark J. Terrill)

(AP) ? For four straight games, the San Antonio Spurs showed off all the teamwork and tenacity that the Los Angeles Lakers lacked all season long.

And when the Lakers' tumultuous season finally collapsed Sunday night, the smooth Spurs rolled right past them to the second round.

Tony Parker scored 23 points, and San Antonio completed its first-round sweep of the injury-plagued Lakers with a 103-82 victory in Game 4.

Tim Duncan had 11 points and six rebounds for the second-seeded Spurs, who will face the winner of Denver's series with Golden State in the second round. They'll get plenty of rest after flattening the Lakers, who staggered through back-to-back blowout losses at home without three regular starters in their first opening-round exit since 2007.

"Obviously, it wasn't a fair fight," Spurs coach Gregg Popovich said. "When you're a competitor, you want to compete on an even basis, and the Lakers weren't able to do that. ... Even though it wasn't a fair fight, we still want to win the series, and I'm glad we did. Our focus was great."

San Antonio never trailed in the clincher, leading by 25 points in one more businesslike effort against the seventh-seeded Lakers, who provided their usual drama right down to their last gasp.

In his final game before unrestricted free agency, Dwight Howard scored seven points before getting ejected early in the third quarter for arguing. Pau Gasol had 16 points for the Lakers, who were swept from the postseason for the second time in three years despite a late courtside appearance by Kobe Bryant on crutches.

"It was just a weird feeling," Parker said. "Obviously, I am happy we won, but it was just weird. They were missing a lot of guys, so we're just happy to go to the next round."

Howard said the season was "like a nightmare. It's like a bad dream, and we just couldn't wake up from it. That's what it felt like."

The Los Angeles Lakers gave away thousands of white towels to their fans Sunday, and they acquired an unfortunate symbolism: In the final game of a season that began with championship aspirations, the Lakers couldn't keep up without injured starters Bryant, Steve Nash and Metta World Peace. They had just nine available players in uniform for the final minutes.

"I'm proud of them, because they fought," Lakers coach Mike D'Antoni said. "It was kind of a year that was all upside-down, but I appreciate the effort to get us into the playoffs. We just didn't have it."

After Duncan led the Spurs' blowout in Game 3, Parker took the lead in the clincher, scoring 15 points in the first half while exploiting the Lakers' hastily assembled backcourt. Los Angeles' top four guards are out with injuries, including backups Steve Blake and Jodie Meeks, and Parker was merciless against third-stringers.

"What I was pleased about our team was that we kept our focus every night," Popovich said. "We played hard, followed the game plan and were very active and energetic every night, and sometimes that's hard to do when your opponent is wounded."

Kawhi Leonard and DeJuan Blair added 13 points apiece in the Spurs' balanced scoring effort. San Antonio trailed for fewer than five combined minutes in the four-game series, grinding out points and defensive stops with the steady professionalism of Popovich's best teams.

"This is a good start for us," Duncan said. "We like the pace we're at right now. We like the rhythm we're at right now, and how healthy we are right now. Hopefully it can stay that way."

After an unimpressive game featuring just two field goal attempts in 20 minutes, Howard was tossed with 9:51 left in the third quarter for his second technical foul. The All-Star center, furious with the Spurs' unpunished physical play, yelled a few parting words at the court after walking past general manager Mitch Kupchak in the tunnel to the locker room.

"I hate it for him," D'Antoni said, lamenting the lack of foul calls against players guarding Howard. "He gets banged up so much in there that I'm sure he didn't mean to (get ejected), but he takes a pounding, and after a while, I guess his nerves were shot."

Moments later, Bryant got the solemn Staples Center crowd on its feet when he hobbled out of the tunnel to a seat behind the Lakers' bench, making his first appearance at courtside since tearing his Achilles tendon 16 days ago. Bryant, who might not be healthy by the start of next season, repeatedly yelled instructions and encouragement at the Lakers' young backcourt, Andrew Goudelock and Darius Morris, and fill-in starter Earl Clark.

The 16-time NBA champion Lakers had high hopes for this season after landing Howard and Nash to play alongside Bryant and Gasol, but their hopes disappeared in an avalanche of injuries, losing streaks and turmoil.

There's almost no turbulence around the Spurs, who seamlessly replaced injured starting center Tiago Splitter in Game 4 with Australian rookie Aron Baynes, who had six points and played decent defense in his first NBA start.

The Spurs had control of this series from the start: They posted two methodical victories at home before sending the Lakers to their biggest home playoff defeat in their long franchise history in Game 3, 120-89. The clincher was more of the same, with the Lakers unable to mount enough teamwork to challenge the smooth Spurs.

The Spurs have swept three of their last four playoff series, winning every game in the first two rounds last season before losing in six games to Oklahoma City in the Western Conference finals. San Antonio is in the second round of the postseason for the fourth time in six seasons since their last championship in 2007.

NOTES: Gasol got a standing ovation when he left the game with 3:08 to play. The two-time NBA champion has one year left on his contract with the Lakers, but could be a trade chip in the Lakers' rebuild. ... Splitter has a sprained ankle and is out indefinitely, although his teammates think he can return during the second round. F Boris Diaw practiced with contact this weekend in his comeback from a back injury. ... The Lakers faced an 0-3 series deficit for the eighth time in franchise history ? and for the eighth time, they were swept. ... Jack Nicholson and Lil Wayne watched at courtside, but both left early in the fourth quarter.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-04-28-BKN-Spurs-Lakers/id-61a675fb1d1a4ee49d77b4c77f214367

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Budget cuts nix $51m in federal work study (The Arizona Republic)

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Skinny Huawei smartphone shows off 6.2mm profile in Chinese certification

Unknown Huawei P6-U06 smartphone shows off 6.2mm profile in Chinese certification

The FCC isn't the only agency playing with devices we don't even know exist, and its Chinese equivalent has recently had some hands-on time with an unknown Huawei smartphone, codename P6-U06. Luckily, there are a few pics and specs to accompany the filing, which tell us it weighs 120g (4.2 ounces) and measures 132.6 x 65.5 x 6.18mm (5.2 x 2.6 x 0.2 inch), meaning it could be one of the super-slim P series handsets a Huawei exec hinted at CES. We didn't see any evidence of these at MWC, but the same exec promised more was to come in 2013, possibly starting with this P6-U06.

Those dimensions house a 4.7-inch TFT screen at 720p resolution, quad-core 1.5GHz processor, 2GB RAM, an 8-megapixel camera on the back and an unusually large 5-megapixel sensor in the shooter up front. Unsurprisingly, Android 4.1.2 Jelly Bean is listed as the OS, while dual-SIM support and GSM / WCDMA radios suggest Asia as the target market (not to mention the Chinese certification). That's all we've got on the P6-U06 for now, but in lieu of official press shots, the handset strikes a couple more candid poses after the break.

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Immigration reform: While Congress debates, Supreme Court stays clear

The US Supreme Court turned aside an appeal on Monday from the state of Alabama asking the high court to examine whether state governments can pass laws making it illegal to harbor or smuggle illegal immigrants within a state?s borders.

The court action came without comment from the justices. The order noted that Justice Antonin Scalia dissented from the court?s decision not to hear the case.

The denial comes as Congress and the White House are working toward an immigration reform package.

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At issue in Alabama v. US (12-884), was an Alabama statute that sought to echo the requirements of federal immigration laws that outlaw similar activities.

It was patterned on a controversial immigration law passed in Arizona in 2010 aimed at discouraging illegal immigrants from coming to or remaining in Arizona.

While Alabama argued that its statute was substantively different from those portions of Arizona?s law previously struck down by the Supreme Court, the justices? refusal to take the case lets stand an appellate court ruling that the Alabama law was preempted by federal immigration law.

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Eight other states have similar laws that seek to regulate activities related to the presence of illegal immigrants within state borders. They were adopted in an attempt to compensate for what state officials viewed as lax or ineffective enforcement of US immigration laws by the federal government.

Like it did regarding Arizona?s SB 1070, the Obama administration opposed the Alabama law and successfully sued the state in federal court to prevent it from enforcing any statute that might touch on issues involving illegal immigrants.

That posture toward the states set the stage for a constitutional confrontation pitting the authority of the national government to set immigration enforcement priorities against the power of the states to protect state residents within their own borders.

The Obama administration?s crackdown against aggressive state immigration laws also dove-tailed with a political strategy in the president?s reelection campaign. Candidate Obama used the state-federal disputes and the promise of a kinder, gentler immigration posture by his administration to appeal to Latino voters.

(It worked. In November, the president received 71 percent of the Latino vote.)

Last June, the Supreme Court invalidated three sections of Arizona?s SB 1070, saying they were preempted by federal immigration law. But the justices also upheld the law?s controversial centerpiece ? the ?show-me-your-papers? provision that ordered police to check the immigration status of anyone they had reason to suspect were in the US without authorization.

The question in the Alabama case was whether Alabama?s anti-harboring statute is preempted by federal immigration laws and the more forgiving immigration enforcement priorities of the Obama administration.

In general, laws passed by Congress are the supreme law of the land and thus preempt state laws that either intrude into an area of federal power or conflict with an existing federal statute.

The portion of the Alabama law that was being appealed involved state prohibitions on harboring, inducing the arrival, or transporting illegal immigrants in Alabama.

?These provisions are markedly different from the ones this court invalidated in [the Arizona case],? Alabama Solicitor General John Neiman wrote in his brief to the court.

Mr. Neiman said that rather than attempting to regulate the actions of the illegal immigrants themselves (an area of federal authority), the Alabama statute sought to regulate state residents engaged in unlawful activity that was related to illegal immigrants.

That distinction, Neiman said, differentiated the anti-harboring law from the portions of the Arizona statute struck down last year by the Supreme Court.

?The United States makes no attempt to justify equating laws that operate directly on aliens with those that operate on citizens,? the Alabama solicitor general wrote.

US Solicitor General Donald Verrilli urged the court to not take up the Alabama case. He said the Eleventh US Circuit Court of Appeals ruled correctly when it decided that the Alabama law was preempted by federal immigration law.

Mr. Verrilli quoted the Supreme Court?s decision in the Arizona case. ?The Government of the United States has broad, undoubted power over the subject of immigration and the status of aliens,? he wrote. ?Whatever power a state may have [related to immigration] is subordinate to supreme national law.?

Washington has wide discretion in every area touching on immigration and immigration enforcement, he said.

?The federal government?s exclusive authority to regulate the terms and conditions of an alien?s entry, movement, and residence in the United States includes the authority to establish criminal sanctions against third parties who facilitate an alien?s violation of those terms and conditions and the authority to decide whether and how such criminal sanctions may be imposed,? the solicitor general said.

?Because Congress has occupied this entire field, even complimentary state regulation is impermissible,? Verrilli wrote. He said the Alabama statute ?stands as an obstacle to the operation of federal law.?

Congress provided that state and local law enforcement officials have the authority to arrest individuals for violations of federal immigration law, but it is up to federal officials to decide when ? or whether ? to prosecute those who are arrested, according to the government?s brief.

Arizona and eight other states had asked the high court to take up Alabama?s appeal. They are Colorado, Florida, Georgia, Indiana, Kansas, Michigan, Oklahoma, and South Carolina.

The states? friend of the court brief said the Eleventh Circuit went too far when it ruled that a state law with any connection to immigration is preempted unless specifically authorized by Congress.

?No interest is more fundamental or substantial than the States? interests in protecting their residents from harm,? the friend of the court brief said.

?Some criminal organizations profit by providing the means for illegal entry or transport, or a safe harbor within the United States for unauthorized aliens,? the brief said. ?Other organized crime groups and terrorists exploit immigrants who seek to come to or remain in the United States by forcing the immigrants to commit other crimes, such as drug running or prostitution.?

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Friday, April 26, 2013

'Taxels' convert mechanical motion to electronic signals

Apr. 25, 2013 ? Using bundles of vertical zinc oxide nanowires, researchers have fabricated arrays of piezotronic transistors capable of converting mechanical motion directly into electronic controlling signals. The arrays could help give robots a more adaptive sense of touch, provide better security in handwritten signatures and offer new ways for humans to interact with electronic devices.

The arrays include more than 8,000 functioning piezotronic transistors, each of which can independently produce an electronic controlling signal when placed under mechanical strain. These touch-sensitive transistors -- dubbed "taxels" -- could provide significant improvements in resolution, sensitivity and active/adaptive operations compared to existing techniques for tactile sensing. Their sensitivity is comparable to that of a human fingertip.

The vertically-aligned taxels operate with two-terminal transistors. Instead of a third gate terminal used by conventional transistors to control the flow of current passing through them, taxels control the current with a technique called "strain-gating." Strain-gating based on the piezotronic effect uses the electrical charges generated at the Schottky contact interface by the piezoelectric effect when the nanowires are placed under strain by the application of mechanical force.

The research will be reported on April 25 in the journal Science online, at the Science Express website, and will be published in a later version of the print journal Science. The research has been sponsored by the Defense Advanced Research Projects Agency (DARPA), the National Science Foundation (NSF), the U.S. Air Force (USAF), the U.S. Department of Energy (DOE) and the Knowledge Innovation Program of the Chinese Academy of Sciences.

"Any mechanical motion, such as the movement of arms or the fingers of a robot, could be translated to control signals," explained Zhong Lin Wang, a Regents' professor and Hightower Chair in the School of Materials Science and Engineering at the Georgia Institute of Technology. "This could make artificial skin smarter and more like the human skin. It would allow the skin to feel activity on the surface."

Mimicking the sense of touch electronically has been challenging, and is now done by measuring changes in resistance prompted by mechanical touch. The devices developed by the Georgia Tech researchers rely on a different physical phenomenon -- tiny polarization charges formed when piezoelectric materials such as zinc oxide are moved or placed under strain. In the piezotronic transistors, the piezoelectric charges control the flow of current through the wires just as gate voltages do in conventional three-terminal transistors.

The technique only works in materials that have both piezoelectric and semiconducting properties. These properties are seen in nanowires and thin films created from the wurtzite and zinc blend families of materials, which includes zinc oxide, gallium nitride and cadmium sulfide.

In their laboratory, Wang and his co-authors -- postdoctoral fellow Wenzhuo Wu and graduate research assistant Xiaonan Wen -- fabricated arrays of 92 by 92 transistors. The researchers used a chemical growth technique at approximately 85 to 90 degrees Celsius, which allowed them to fabricate arrays of strain-gated vertical piezotronic transistors on substrates that are suitable for microelectronics applications. The transistors are made up of bundles of approximately 1,500 individual nanowires, each nanowire between 500 and 600 nanometers in diameter.

In the array devices, the active strain-gated vertical piezotronic transistors are sandwiched between top and bottom electrodes made of indium tin oxide aligned in orthogonal cross-bar configurations. A thin layer of gold is deposited between the top and bottom surfaces of the zinc oxide nanowires and the top and bottom electrodes, forming Schottky contacts. A thin layer of the polymer Parylene is then coated onto the device as a moisture and corrosion barrier.

The array density is 234 pixels per inch, the resolution is better than 100 microns, and the sensors are capable of detecting pressure changes as low as 10 kilopascals -- resolution comparable to that of the human skin, Wang said. The Georgia Tech researchers fabricated several hundred of the arrays during a research project that lasted nearly three years. The arrays are transparent, which could allow them to be used on touch-pads or other devices for fingerprinting. They are also flexible and foldable, expanding the range of potential uses.

Among the potential applications:

? Multidimensional signature recording, in which not only the graphics of the signature would be included, but also the pressure exerted at each location during the creation of the signature, and the speed at which the signature is created.

? Shape-adaptive sensing in which a change in the shape of the device is measured. This would be useful in applications such as artificial/prosthetic skin, smart biomedical treatments and intelligent robotics in which the arrays would sense what was in contact with them.

? Active tactile sensing in which the physiological operations of mechanoreceptors of biological entities such as hair follicles or the hairs in the cochlea are emulated. Because the arrays would be used in real-world applications, the researchers evaluated their durability. The devices still operated after 24 hours immersed in both saline and distilled water.

Future work will include producing the taxel arrays from single nanowires instead of bundles, and integrating the arrays onto CMOS silicon devices. Using single wires could improve the sensitivity of the arrays by at least three orders of magnitude, Wang said. "This is a fundamentally new technology that allows us to control electronic devices directly using mechanical agitation," Wang added. "This could be used in a broad range of areas, including robotics, MEMS, human-computer interfaces and other areas that involve mechanical deformation."

This research was supported by the Defense Advanced Research Projects Agency (DARPA), the National Science Foundation (NSF) under grant CMMI-0946418, the U.S. Air Force (USAF) under grant FA2386-10-1-4070, the U.S. Department of Energy (DOE) Office of Basic Energy Sciences under award DE-FG02-07ER46394 and the Knowledge Innovation Program of the Chinese Academy of Sciences under grant KJCX2-YW-M13. The content is solely the responsibility of the authors and does not necessarily represent the official views of DARPA, the NSF, the USAF or the DOE.

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Journal Reference:

  1. Wenzhuo Wu, Xiaonan Wen, Zhong Lin Wang. Taxel-addressable matrix of vertical-nanowire piezotronic transistors for active/adaptive tactile imaging. Science, 2013 DOI: 10.1126/science.1234855

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/electronics/~3/-jrj0Z-Yh-E/130425142247.htm

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Autism risk spotted at birth in abnormal placentas

Apr. 25, 2013 ? Researchers at the Yale School of Medicine have figured out how to measure an infant's risk of developing autism by looking for abnormalities in his/her placenta at birth, allowing for earlier diagnosis and treatment for the developmental disorder. The findings are reported in the April 25 online issue of Biological Psychiatry.

One out of 50 children are diagnosed with an autism spectrum disorder in the United States each year, according to the Centers for Disease Control and Prevention (CDC), but the diagnosis is usually made when these children are 3 to 4 years of age or older. By then the best opportunities for intervention have been lost because the brain is most responsive to treatment in the first year of life.

Senior author Dr. Harvey Kliman, research scientist in the Department of Obstetrics, Gynecology & Reproductive Sciences at the Yale School of Medicine, and research collaborators at the MIND Institute at the University of California, Davis, have found that abnormal placental folds and abnormal cell growths called trophoblast inclusions are key markers to identify newborns who are at risk for autism.

Kliman and his team examined 117 placentas from infants of at-risk families, those with one or more previous children with autism. These families were participating in a study called Markers of Autism Risk in Babies -- Learning Early Signs. Kliman compared these at-risk placentas to 100 control placentas collected by the UC Davis researchers from the same geographic area.

The at-risk placentas had as many as 15 trophoblast inclusions, while none of the control placentas had more than two trophoblast inclusions. Kliman said a placenta with four or more trophoblast inclusions conservatively predicts an infant with a 96.7% probability of being at risk for autism.

Currently, the best early marker of autism risk is family history. Couples with a child with autism are nine times more likely to have another child with autism. Kliman said that when these at-risk families have subsequent children they could employ early intervention strategies to improve outcomes. "Regrettably couples without known genetic susceptibility must rely on identification of early signs or indicators that may not overtly manifest until the child's second or third year of life," said Kliman.

"I hope that diagnosing the risk of developing autism by examining the placenta at birth will become routine, and that the children who are shown to have increased numbers of trophoblast inclusions will have early interventions and an improved quality of life as a result of this test," Kliman added.

Other authors on the study include Kaitlin Anderson, Kristin Milano, and Saier Ye of Yale University; and Cheryl Walker, Daniel Tancredi, Isaac Pessah, and Irva Hertz-Picciotto of UC Davis.

This work was supported by the National Institutes of Health (1 P01 ES11269 and R01 ES 015359), the U.S. Environmental Protection Agency through the Science to Achieve Results (STAR) program (R829388 and R833292), the MIND Institute at the University of California, Davis, and the Yale University Reproductive and Placental Research Unit.

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The above story is reprinted from materials provided by Yale University. The original article was written by Karen N. Peart.

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Journal Reference:

  1. Cheryl K. Walkera, Kaitlin W. Andersong, Kristin M. Milanoh, Saier Yei, Daniel J. Tancredie, Isaac N. Pessahc, Irva Hertz-Picciottob, Harvey J. Klimang. Trophoblast Inclusions Are Significantly Increased in the Placentas of Children in Families at Risk for Autism. Biological Psychiatry, 2013 DOI: 10.1016/j.biopsych.2013.03.006

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/7OtN05U-7iQ/130425091604.htm

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Thursday, April 25, 2013

Dental records of missing Brown student requested after body found in river

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By Dan Stamm, NBCPhiladelphia.com

The family of missing Brown University student Sunil Tripathi has been asked to provide dental records to the medical examiner in Providence, R.I.

The ME?is trying to identify the body of a man that was pulled from the Providence River late Tuesday afternoon. According to the lead investigator on the case, the ME expects to release the identity of the victim either Thursday or Friday.

Tripathi, 22, who is from Bryn Mawr, Pa., has been missing since March 16.?He was last seen on surveillance video early that morning, not far from his apartment on Brook Street, near campus.

The body was found by members of the school's crew team in the water near India Point Park, which is a few blocks away from Tripathi's apartment. Police on the scene said the body appeared to be that of a man in his 20s.

When reached by phone, Tripathi's brother Ravi told NBC10's Monique Braxton that the family is in Providence?and aware of the report. They?don't plan on commenting until the ME has determined the identity.

Tripathi, a graduate of Radnor High School, moved to Providence?to attend Brown. He was studying philosophy but took a leave this semester. Sunil battles depression and was working through a "tough time," his sister Sangeeta said last month. The family felt that in the weeks before he disappeared, however, Sunil was doing well.?

On the day his brother went missing, Ravi Tripathi made the trip from Philadelphia to Providence as fast as he could.

?We dropped everything. We didn?t even pack. And then a couple of days turned into over a month.?

Since then -- 38 days now -- Providence has been ground zero in the search for Sunil Tripathi. His immediate family, extended family and close friends are all there together. Every day they meet and collaborate on what they can do next.

Last week Sunil's case was thrust back into the spotlight following?a viral onslaught of erroneous speculation that Tripathi was connected to the Boston Marathon bombings.

"It's a very scary thing to be on the other side of it and see how quickly our voices got drowned out and hysteria took over,"?Ravi Tripathi said in an interview on Monday.

The Tripathi family has been posting the latest information and messages of hope on their ?Help Us Find Sunil Tripathi? Facebook page.

"It's been a roller coaster for all of us," Ravi said earlier this week, reflecting back on the five weeks they've spent searching for Sunil.? Ravi said he would always be grateful for the time everyone has spent together, saying the support of family and friends has been "beautiful. A gift."

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Video: Scientists advance understanding of human brown adipose tissue and grow new cells

Video: Scientists advance understanding of human brown adipose tissue and grow new cells

Tuesday, April 23, 2013

Joslin scientists report significant findings about the location, genetic expression and function of human brown adipose tissue (BAT) and the generation of new BAT cells. These findings, which appear in the April 2013 issue of Nature Medicine, may contribute to further study of BAT's role in human metabolism and developing treatments that use BAT to promote weight loss.

Two types of adipose (fat) tissue ? brown and white -- are found in mammals. Unlike the more predominant white adipose tissue (WAT) which stores fat, BAT burns fat to produce heat when the body is exposed to cold and also plays a role in energy metabolism. Human studies have shown that greater quantities of BAT are associated with lower body weight. BAT has been a major focus of study among scientists and pharmaceutical companies based on its potential as a treatment to combat obesity, a major risk factor for type 2 diabetes.

Studies in mice have identified two types of BAT: constitutive or "classical" BAT which is present at birth and persists throughout life and recruitable or "beige" BAT which can be produced from within white fat in response to metabolic conditions. These two types of BAT may also be present in humans.

Previous studies have identified the human neck as a primary location for BAT deposits. To determine the precise locations of these deposits, Joslin scientists obtained fat samples from five neck regions of patients undergoing neck surgery. Analysis of the samples showed that BAT was most abundant in deep regions of the neck, near the carotid sheath and longus colli muscles. These samples expressed the BAT marker gene, uncoupling protein 1 (UCP1), which is involved in heat generation. "BAT is most abundant in the deep locations of the neck, close to the sympathetic chain and the carotid arteries, where it likely helps to warm blood and raise body temperature. Now that we know where brown fat is, we can easily collect more cells for further study," says Aaron M. Cypess, M.D., Ph.D., senior author and Assistant Investigator in the Section of Integrative Physiology and Metabolism and Assistant Professor at Harvard Medical School.

In analyzing genetic expression in superficial and deep human neck fat tissue, the fat from deep locations was found to most closely resemble cells from constitutive mouse BAT, the kind already known to consume large quantities of glucose and fat.

The Joslin scientists compared the oxygen consumption rate (OCR), which demonstrates the capacity to burn calories, of human BAT cells to mouse constitutive BAT cells and human WAT. This is the first study to directly measure brown fat cells' OCR at baseline. The OCR of the human BAT cells from the deep location next to the longus colli was nearly 50 percent of the mouse BAT cells; in contrast, the OCR of human WAT was only one-hundredth of the OCR found in the most active human BAT from the longus colli depot. "We show that at baseline, brown fat cells have a great capacity to burn fat," says Dr. Cypess.


Joslin scientists report significant findings about the location, genetic expression and function of human brown adipose tissue (BAT) and the generation of new BAT cells. These findings, which appear in the April 2013 issue of Nature Medicine, may contribute to further study of BAT's role in human metabolism and developing treatments that use BAT to promote weight loss. Credit: Joslin Communications

The scientists were able to grow new functional brown fat cells (adipocytes) by differentiating precursor cells (preadipocytes) derived from both superficial and deep human neck fat tissue. When stimulated, the cells expressed the same genes as naturally occurring brown fat cells. This is the first report of the production of brown fat cells (adipogenesis) that can respond to pharmacological stimulation.

The Joslin scientists are following up on this study to learn more about the functions of BAT, including how it affects energy balance and uses glucose. Having the ability to produce brown fat cells outside the body will make it possible to develop drugs and other potential treatments that increase BAT activity to combat obesity. "Our research has significant practical applications. If we stimulate the growth of brown fat in people, it may burn their white fat and help them lose weight, which lessens insulin resistance and improves diabetes," says Dr. Cypess.

###

Joslin Diabetes Center: http://www.joslin.org

Thanks to Joslin Diabetes Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127868/Video__Scientists_advance_understanding_of_human_brown_adipose_tissue_and_grow_new_cells

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Wednesday, April 24, 2013

Senate DFLers want to raise income taxes for wider group, tax clothing (Star Tribune)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

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CA-BUSINESS Summary

TSX slips as gold, energy shares drag

TORONTO (Reuters) - Canada's main stock index turned lower in early Tuesday trade, with weakness in commodity prices weighing on shares of gold and energy companies, as weak economic data from China and Germany dampened investor sentiment. The Toronto Stock Exchange's S&P/TSX composite index <.gsptse> was down 22.83 points, or 0.19 percent, at 12,067.85, after opening higher.

Manufacturing data stokes fears of global spring swoon

NEW YORK/LONDON (Reuters) - Major economies in North America, Europe and Asia lost some momentum this month, a clutch of business surveys showed on Tuesday, raising concerns about the strength of the global recovery. China and Germany, the world's biggest exporters, both lost momentum in April. Growth in Chinese factories slowed to a crawl as export demand dwindled, while the euro zone's largest economy saw business activity decline for the first time in five months.

Canadian February retail sales rise more than expected

OTTAWA (Reuters) - Canadian retail sales in February rose a greater-than-expected 0.8 percent from January, pushed up by higher sales at general merchandise stores and gas stations, Statistics Canada data indicated on Tuesday. The increase was greater than the 0.3 percent advance predicted by market operators. Statscan trimmed January's growth to 0.9 percent, from an initial 1.0 percent.

NTSB looks for cause, larger lessons in Boeing 787 battery fire

WASHINGTON (Reuters) - The top U.S. transportation safety regulator is looking beyond what caused a Boeing Co Dreamliner battery to fail in January at larger lessons that can be applied to the airplane certification process and new technologies. A two-day hearing at the National Transportation Safety Board headquarters in Washington that began on Tuesday is part of the agency's investigation into what caused a battery to catch fire and burn on a parked 787 Dreamliner in Boston in January. The battery fire occurred after passengers had deplaned, and workers noticed smoke in the cabin. It took firefighters more than an hour to put the fire out.

Bank of Canada repeats language on higher interest rates

OTTAWA (Reuters) - Outgoing Bank of Canada Governor Mark Carney on Tuesday repeated the central bank's warning that it expects its next move to be an interest rate increase, even after recently cutting growth forecasts. "The considerable monetary policy stimulus currently in place will likely remain appropriate for a period of time, after which some modest withdrawal will likely be required, consistent with achieving the 2 per cent inflation target," he told a Canadian parliamentary committee.

Global survey reveals unhappiness with retail banks

LONDON (Reuters) - Banks have made little progress in improving customer service over the past year, with around a half of their retail customers considering switching to a rival, according to a survey published on Tuesday. The 2013 World Retail Banking Report from Capgemini , which polls over 18,000 retail banking customers in 35 countries, found that 41 percent of customers were unsure if they would stay with their bank in the next six months, while an additional 10 percent indicated that they would leave.

TransAlta posts loss on pension funding

(Reuters) - Canadian power generation company TransAlta Corp reported a first-quarter loss, hurt in part by a one-time charge related to pension funding obligations. The company posted a loss of C$11 million, or 4 Canadian cents per share, in the first quarter, compared with a profit of C$88 million, or 39 Canadian cents per share, a year earlier.

Encana operating profit falls on hedging losses

(Reuters) - EnCana Corp , Canada's No.1 natural gas producer, reported a 25 percent fall in first-quarter operating profit due to hedging losses. Encana's net operating income, which excludes most one-time items, fell to $179 million, or 24 cents per share, in the first quarter, from $240 million, or 33 cents per share, a year earlier.

Euro zone slump moderates but German worries appear: PMIs

LONDON (Reuters) - A sharp drop in German business activity overshadowed an easing downturn in France in April, surveys showed on Tuesday, raising concerns over a further economic contraction in the euro zone. Markit's flash euro zone services PMI, an early gauge of business activity each month, rose to 46.6 in April from 46.4 in March, below the 50 line that divides growth from contraction but matching the forecast of economists.

Xerox steps up restructuring, second-quarter EPS goal below Street

(Reuters) - Xerox Corp on Tuesday forecast second-quarter earnings below estimates as it accelerates its restructuring efforts to become a broader technology company. In an attempt to counter sluggish growth in its technology business, which includes printers and copiers, Xerox has been transforming itself into a business services provider, offering services such as managing toll systems and healthcare programs.

Source: http://news.yahoo.com/ca-business-summary-114755430.html

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Tuesday, April 23, 2013

Moxie Software Offers Freemium Service, Integrating Collaboration Spaces With Social Knowledge Engine

moxiesoftwareMoxie Software has announced a new freemium service that integrates its collaboration service with its social knowledge engine. Under the new plan,?Collaboration Spaces?is?now free for anyone to use with no limits on users and full features that come with the SaaS offering. The social knowledge engine integration is offered as a premium service that can be integrated with Collaboration Spaces. The cost of the premium social knowledge engine is based upon the number of users on the plan. Moxie’s model is based on the premise that general collaboration has only limited value. It’s good for sharing information, but the real context comes when business processes and analytics integrate into users’ workflows. The social knowledge engine is designed to give answers to questions. With the new premium service, answers that surface in Collaboration Spaces become part of the social knowledge engine and are fed back so actions can be taken quickly. The new service follows Moxie’s announcement last fall that it would provide the ability for customers to tap into the Facebook social graph to determine the best time to engage with people on a brand?s Facebook page. The Facebook service and the new social knowledge engine integration with Collaboration Spaces shows how Moxie is developing use-case-specific ways for contact centers in particular to use its technology. Moxie?sees itself differentiating from services like Jive and Yammer that charge by the user or the enterprise plan and offer general collaboration services.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/eqE209VVNYI/

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Monday, April 22, 2013

Deal of the Day ? 20? HP Pavilion 20xi 1600 X 900 IPS LED-backlit LCD monitor

Monday’s LogicBUY Deal is the?20″ HP Pavilion 20xi LED-backlit LCD monitor with IPS panel (C4D33AA#ABA) for?$94.99. ?Features: VGA and DVI inputs (cables included) 10,000,000:1 dynamic contrast ratio 250 nit brightness 7ms response time 1-year warranty $129.99 – $20 instant savings -?$15 coupon code?= $94.99 with free shipping. This deal expires April 23, 2013 or sooner. [...]

Source: http://the-gadgeteer.com/2013/04/22/deal-of-the-day-20-hp-pavilion-20xi-1600-x-900-ips-led-backlit-lcd-monitor/

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Saturday, April 20, 2013

EU-U.S. trade deal seen reaping rapid benefit

By Philip Blenkinsop

DUBLIN (Reuters) - Companies would race to profit from a free trade agreement (FTA) between the European Union and the United States, bringing a near instant boost to both economies, the head of the U.S. Chamber of Commerce said.

"If they made a deal tomorrow, U.S. and European companies are sitting on a boatload of cash and they'd be moving this thing up as fast as they can move," Thomas Donohue, president of the U.S. Chamber of Commerce, said after a EU-U.S. trade conference in Dublin.

The 27-member bloc and the United States are likely to launch negotiations on a trade deal by the end of June, with discussions set to last at least two years, meaning an accord could enter into force by 2016.

The deal could add 0.5 and 0.4 percent respectively to European and U.S. gross domestic product, according to a European Commission (EC) report, although it could take a decade to deliver those effects.

Donohue said a deal could deliver benefits more quickly than suggested by the EC report.

"You open a door and say there's money on the other side, there's opportunity to expand, to export, to sell their products, to make partnerships ... You think they're going to wait around till 2027? They'll be through the door before you know it," he said in an interview.

Donohue said it was important politicians and trade officials move quickly and conclude a comprehensive deal as soon as possible.

"There are a lot of people sitting around saying, well we have to take our time. We don't need to take our time. We got millions of people looking for a job," he said.

Donohue said he was optimistic on the prospects of agreeing a free trade alliance, which would remove tariffs and reduce other barriers to trade, if only because both partners were desperate for growth to cut unacceptably high unemployment.

"I believe they will do that for the following reasons: they must, they need to," he said.

The White House notified Congress last month of its plans to begin free trade talks with Europe, in an effort to capitalize on the world's largest trade and investment relationship to spur growth.

(Editing by Patrick Graham and David Holmes)

Source: http://news.yahoo.com/eu-u-trade-deal-seen-reaping-rapid-benefit-093705063--business.html

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Friday, April 19, 2013

Twitter launches iTunes-connected #music app for iOS

Twitter Music

This morning Twitter announced #music, a new app which allows Twitter users to post and listen to embedded tracks from iTunes, Spotify, or Rdio. By checking out the new #NowPlaying section, you can get a snapshot view of what's being listened to by the people you follow. For those looking for something new, you can flip through the Suggested, Emerging, and Popular sections. If you're a subscriber to either Spotify or Rdio, you can listen to the full tracks, but otherwise you just get an iTunes preview. Links are provided to the Twitter accounts of performing artists from the playback window, along with options to share the track yourself.

What's particularly interesting about this whole thing is that #music isn't just folded into the native Twitter app; it's an entirely separate app altogether. It's certainly cool that Twitter's making new apps, but I can't help but feel that this feature could have been a huge differentiator to the native Twitter client. It also feels like the iTunes connection could be a bit stronger than simply pulling in previews and linking off to the store; Twitter was cozy with Ping once upon a time, after all.

The initial rollout for Twitter #music is taking place in the U.S., Canada, UK, Ireland, Australia, and New Zealand. An Android roll-out and wider international spread are in the works, but in the meantime, they can still enjoy the web version. Spotify and Rdio customers, are you pumped about the new service? Those of you that aren't subscribers, could a social engine like this get you to sign up? Could you see yourself buying a track through iTunes that was discovered through Twitter #music?

Source: Twitter

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/QGejKEH0YFU/story01.htm

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Thursday, April 18, 2013

Zester Daily: Chef Susan Feniger's Travel-Inspired Dishes

2013-04-16-SusanFeniger.Credit.DavidLatt.ZesterDaily.jpg

By David Latt
Susan Feniger, one of Los Angeles' best-known restaurateurs, is always planning her next food trip, as soon as she comes home. Feniger's restaurant Street, which opened in 2009, is inspired by the global street-food scene, but her explorations are as much about experiencing the lives people lead as they are about finding travel-inspired recipes.

Talking about a trip to the Turkish countryside, her eyes brightened as she described going with a friend to meet a farmer he knew. A walk into the fields up from the river led them to a house made of sticks with a cow in front. Inside, the kitchen had a fire pit in the middle of the room.

Related: Cookbook author Deborah Madison explains the secret to vegetables.

Sitting on the floor for their meal, Feniger watched with pleasure as the farmer's wife first made tahini by grinding sesame seeds and then baked the tahini into the bread for their midday meal. The bread was delicious, as was the experience.

In her kitchen at Street, Feniger demonstrated one of the popular dishes on the menu, an easy-to-make dish with lots of flavor: Brussels sprouts flavored with goat cheese, apples and hazelnuts, topped with an Italian version of a picada without nuts.

When Feniger and Mary Sue Milliken, her longtime cookbook collaborator and fellow chef, were doing research for the dishes they would serve at their second restaurant, Border Grill, they traveled extensively in Mexico. She quickly discovered that the food she loved was the food cooked by street vendors and in people's home.

Related: Chinese brussels sprouts with satay sauce.

As she explained, When you go into people's homes "they're so happy you're there eating their food. People took us into their homes because they wanted us to taste their food. You didn't get that if you go to restaurants. When you are on the street and you are in a culture that doesn't usually see [outsiders], they really like that [you are willing to try their food]."

To Feniger, eating the food prepared by people for their everyday lives is how you see the heart of a country. Over the years she has traveled around the world, pursuing her love of culture and eating.

"When I travel, if I don't see a historical site, I'm ok. The much more rewarding experiences are the ones with people in their kitchens. My memories when I travel are ones with people, not with the monuments."

Related: The best way to cook brassica vegetables.

On a 14-day trip, crisscrossing India from Delhi to Mumbai to Goa to Kerala (her favorite), Feniger ate on the street or in people's homes every day. ... When she was in Shanghai she was taken by a local on a food tour that began at 4 a.m. so she could watch a man make savory fresh soy milk sticky rice doughnuts cooked in a wok. By 8 a.m., he had finished his breakfast service so he cleaned up and left, allowing a shoe repairman to take over the stall.

The menu at Street cherry-picks taste treats she ate during her travels over several decades.

Recently, Feniger revamped the Street menu and gently moved in the direction of vegetarianism, not for policy reasons but because the street food she loves tends to feature produce over animal products.

Related: Brussels sprouts salad with apples, walnuts and maple syrup.

Hence, the Brussels sprouts dish. Her picada is Italian and illustrates Feniger's belief that keeping it simple is best. Take a run at flavor, she suggests, letting the ingredients lead you and everyone will be happy.

Brussels Sprouts with Goat Cheese, Apples and Hazelnuts

?

Video: Watch Susan Feniger prepare saut?ed Brussels sprouts in her kitchen at Street

Cooked quickly, the Brussels sprouts should be crunchy so the dish tastes fresh and inviting. The contrast of savory Brussels sprouts, sweet apples and tart-creamy goat cheese, together with accents of the picada make the dish delicious on its own or as a side dish with a protein such as saut?ed tofu, fried chicken, grilled steak or baked salmon.

Serves 4

Ingredients

For the saut?:

? cup raw hazelnuts

1? tablespoons olive oil

6 cups whole Brussels sprouts, shaved thinly on a mandolin or with a knife

2 medium sized Granny Smith apples, cored and cut into a small dice

Juice of 1 lemon

6 ounces soft goat cheese, broken into small pieces

1 teaspoon kosher salt

For the picada:

? cup extra virgin olive oil

2 tablespoons minced raw garlic

2 cups bread crumbs

Salt to taste

zest of 3 lemons

1 bunch Italian parsley, finely chopped

Directions

For the saut?:

1. Preheat oven to 350 F.

2. Spread the hazelnuts out on a cookie sheet and toast them for 5 to 10 minutes until they are roasted and slightly browned.

3. Remove from heat and pour onto a clean dish towel.

4. Fold the dish towel over the toasted hazelnuts and roll lightly to remove the skins. Discard the skins.

5. Place the hazelnuts on a cutting board and chop into small pieces, or alternately pulse in a food processor for a brief period of time. Set aside.

6. In a large saut? pan, heat the oil on medium-high heat.

7. Add the Brussels sprouts, apples and salt, and cook, stirring occasionally, until the Brussels sprouts are slightly browned on the edges.

8. Add the hazelnuts, lemon juice and goat cheese.

9. Toss together and turn off heat.

For the picada:

10. In a large saut? pan heat the oil, but do not let it smoke.

11. Add the garlic and stir quickly to release its flavors, but do not brown.

12. As the garlic starts to color, add the bread crumbs and salt to taste.

13. Stir well to combine and toast in the oil (about 5 minutes).

14. When the bread crumbs are browned, remove from heat and place in a mixing bowl.

15. Add the lemon zest and the parsley while the bread is still slightly warm.

16. Toss and then spread out on a cookie sheet to cool to room temperature. Store in an airtight container before using.

17. Sprinkle on top of the Brussels sprouts before serving.

Top photo: Susan Feniger in her kitchen at Street, demonstrating how to make Brussels sprouts with goat cheese, apples and hazelnuts. Credit: David Latt

More from Zester Daily:

? Elin McCoy's wine of the week: a Pinot Noir that delights.

? Canning, drying and pickling are easy, smart and sustainable. Here's how.

? Find chefs' favorite hole-in-the-wall restaurants on this app.

? Busting fish myths: Easy tips to prepare healthy seafood.

?

Follow Zester Daily on Twitter: www.twitter.com/@ZesterDaily

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Source: http://www.huffingtonpost.com/zester-daily/susan-feniger-recipes_b_3094128.html

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Groups sue to block Arkansas' 12-week abortion ban

Rita Sklar, executive director of the American Civil Liberties Union of Arkansas, speaks during a news conference at the Arkansas state Capitol in Little Rock, Ark., Tuesday, April 16, 2013. Abortion rights proponents filed a federal lawsuit Tuesday to block Arkansas' new abortion law, which is among the most restrictive in the nation. (AP Photo/Danny Johnston)

Rita Sklar, executive director of the American Civil Liberties Union of Arkansas, speaks during a news conference at the Arkansas state Capitol in Little Rock, Ark., Tuesday, April 16, 2013. Abortion rights proponents filed a federal lawsuit Tuesday to block Arkansas' new abortion law, which is among the most restrictive in the nation. (AP Photo/Danny Johnston)

Sen. Jason Rapert, R-Conway, a lead sponsor of a law banning most abortions from the 12th week of pregnancy onward, walks to the Senate at the Arkansas state Capitol in Little Rock, Ark., Tuesday, April 16, 2013. Abortion rights proponents filed a federal lawsuit Tuesday to block the new abortion law(AP Photo/Danny Johnston)

(AP) ? A pair of advocacy groups went to federal court Tuesday claiming that Arkansas' legislators violated the constitutional rights of two doctors, and their potential patients, by banning nearly all abortions beginning in the 12th week of pregnancy.

The American Civil Liberties Union of Arkansas and the Center for Reproductive Rights, which filed the suit on behalf of Dr. Louis Jerry Edwards and Dr. Tom Tvedten, who provide abortions at a Little Rock clinic, say Arkansas' ban clearly contradicts the standard of viability established by the U.S. Supreme Court's landmark Roe v. Wade decision.

"We are asking the court to block an attempt to essentially outlaw all abortions past 12 weeks, so early that a woman might not know the complete health and status of her pregnancy," Rita Sklar, executive director of Arkansas' ACLU chapter, said at a news conference.

When the Republican-led Legislature passed the law last month, it was briefly the most restrictive abortion law in the country, including a near-ban at 20 weeks that it passed a week earlier. In each case, lawmakers overrode a veto by Democratic Gov. Mike Beebe, who predicted that neither law would stand up in court and that Arkansas would waste money defending them.

North Dakota has since passed and even tighter restriction: 6 weeks.

The lawsuit contends that Edwards and Tvedten could lose their licenses if they provide abortions starting at the 12th week of pregnancy, meaning the law denies "patients their constitutionally-guaranteed right to decide to end a pre-viability pregnancy." It names members of the State Medical Board as defendants because the board is responsible for licensing medical professionals.

Arkansas' 12-week ban is tied to the date at which a fetal heartbeat can typically be detected by an abdominal ultrasound. The ban includes exemptions for rape, incest, the life of the mother and highly lethal fetal disorders.

The lawsuit filed Tuesday does not challenge Arkansas' 20-week measure, as challenges to similar laws in other states are already pending. The 20-week ban is based on the disputed claim that a fetus can feel pain by the 20th week and therefore deserves protection from abortion. It includes the same exemptions as the 12-week ban, except for fetal disorders.

Rose Mimms, the executive director of Arkansas Right to Life, said anti-abortion groups like hers are hopeful that the new abortion restrictions being passed in conservative-leaning states will land before the U.S. Supreme Court and be considered against new discoveries regarding fetal development.

"They didn't have that kind of information when they decided Roe v. Wade," Mimms said, referring to the 1973 decision that legalized abortion until a fetus could viably survive outside the womb. A fetus is generally considered viable at 22 to 24 weeks.

Arkansas' ban on abortions at 20 weeks took effect immediately when legislators overrode Beebe's veto. The 12-week ban is scheduled to take effect 90 days after the Legislature adjourns, which could occur late this week or early next week.

Sklar said the Supreme Court has recognized that the Constitution protects a woman's ability to make her own decision regarding abortions.

"But our state Legislature ignored the law and voted to take a woman's decision-making ability away," Sklar said.

A lead sponsor of the 12-week ban, Republican state Sen. Jason Rapert, said he hadn't seen the lawsuit yet, but he said it wasn't a surprise.

"We definitely are planning to defend it," he said. "It's a law duly passed by the state of Arkansas."

___

Associated Press writer Andrew DeMillo contributed to this report.

___

Follow Jeannie Nuss at http://twitter.com/jeannienuss

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2013-04-16-US-Abortion-Ban-Arkansas/id-7ed0bb5c17cb428796c6365a2759da73

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