Monday, December 24, 2012

The Google Of The App Search Era Just Might Be Google

android-eats-appleOnly a few years in, and already the mobile application ecosystem has become an unfathomable jungle of applications - some 700,000-plus in the two top mobile app stores, Apple's App Store and Google Play. And yet, we're still waiting for the Google of the mobile app era to come in and save us from the mess that is today's app market. A search engine that uses not just dozens of signals, but thousands, to help the everyday user connect with the apps they are searching for. It's possible, though, that the Google we're still waiting for is actually Google itself.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/Rx19eRO_Jos/

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Pro-gun rights petition U.S. to deport CNN's Piers Morgan

LONDON (AP) ? Tens of thousands of people have signed a petition calling for British CNN host Piers Morgan to be deported from the U.S. over his gun control views.

Morgan has taken an aggressive stand for tighter U.S. gun laws in the wake of the Newtown, Connecticut, school shooting. Last week, he called a gun advocate appearing on his "Piers Morgan Tonight" show an "unbelievably stupid man."

Now, gun rights activists are fighting back. A petition created Dec. 21 on the White House e-petition website by a user in Texas accuses Morgan of engaging in a "hostile attack against the U.S. Constitution" by targeting the Second Amendment. It demands he be deported immediately for "exploiting his position as a national network television host to stage attacks against the rights of American citizens."

The petition has already hit the 25,000 signature threshold to get a White House response. By Monday, it had 31,813 signatures.

Morgan seemed unfazed ? and even amused ? by the movement.

In a series of Twitter messages, he alternately urged his followers to sign the petition and in response to one article about the petition said "bring it on" as he appeared to track the petition's progress.

"If I do get deported from America for wanting fewer gun murders, are there any other countries that will have me?" he wrote.

Source: http://news.yahoo.com/pro-gun-rights-us-petition-deport-piers-morgan-130319681.html

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Cancer Immunotherapy?Where Are We Going?

The compelling concept of utilizing the patient?s own immune system for a stronger and more effective way to attack cancer cells is not a new one. William Coley observed in 1891 that infections produced in patients with inoperable cancer following an injection of streptococcal organisms (Gram-positive bacteria) led to tumor shrinkage especially when the patients developed fever and other signs of a full-blown infection.1 Since then, research has embraced approaches to ?train? the patient?s own immune system to recognize certain biomarkers or proteins that are mainly found on cancer cells and to destroy the cells.

After several setbacks the first cellular immunotherapy, Dendreon?s Sipuleucel-T (Provenge?), was approved for the treatment of prostate cancer in 2010. Today, new promising cancer immunotherapy approaches are in clinical trials. Most recently, researchers at the 54th American Society of Hematology (ASH) meeting reported early success with a developmental-stage cell-based cancer vaccine for the treatment of leukemia and have shown remission in several patients 2,3, including a 7-year old girl who relapsed twice after chemotherapy.

Cancer immunotherapy can be thought of as either active or passive immunotherapy. The most prominent passive immunotherapies, which have revolutionized cancer therapy, are monoclonal antibodies that either target tumor-specific antigens and receptors or block important pathways central to tumor growth and survival. Therapeutic monoclonal antibodies are the market leader in the targeted cancer therapy space and include blockbusters such as trastuzumab (Herceptin?) or rituximab (Rituxan?).

In general, antibodies are significant elements of the body?s adaptive immune system. They play a dominant role in the recognition of foreign antigens and the stimulation of the immune response. Therapeutic antibodies target and bind to antigens, usually proteins that are mainly expressed on diseased cells such as cancer cells. After binding, cancer cells can be destroyed by different mechanisms such as antibody-dependent cellular cytotoxicity, the activation of the complement system ? an important part of the immune system ? and triggering cell death.

Although very successful, especially in oncology, therapeutic antibodies have a significant limitation: they don?t generate a memory response by the immune system, and thus, repeated antibody infusions are required. Further, monoclonal antibodies are only able to recognize specific proteins present of the cell surface. Monoclonal antibodies are mostly produced in cell culture systems which are often costly. Humanization of murine monoclonal antibodies by replacing of certain parts of the antibody with human sequences has improved the tolerability of antibodies and made them less immunogenic, but even fully human sequence-derived antibodies can carry some immunological risk.

Novel approaches in the passive immunization strategy include antibody drug conjugates, a combination of targeting antibody with a very potent drug such as the recently approved brentuximab vedotin (ADCETRIS?) for Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). ADCETRIS comprises an anti-CD30 monoclonal antibodyanti-CD30 monoclonal antibody and a cytotoxic (cell-killing) agent that is released upon internalization into CD30-expressing tumor cells. Currently, the development of next generations of ADCs is underway.

Alternatively, specific and durable cancer immunotherapies designed to actively ?train? or stimulate the patient?s intrinsic immune response have been more problematic; however, recent success stories, such as the cell-based immunotherapy Provenge, have revitalized this field. Dendreon?s approach modifies the patients? own dendritic cells to present a protein specific to prostate cancer cells.

Dendritic cells are the most potent, ?professional? antigen-presenting cells. They process the antigen material and present it on their surface to other cells of the immune system. Once activated, the dendritic cells migrate to the lymphoid tissues where they interact with T-cells and B-cells ? white blood cells and important components of the immune system ? to initiate and shape the adaptive immune response. To develop Provenge, each patient?s own dendritic cells are harvested and then loaded ex vivo with the tumor-associated antigen. Now ?presenting? the antigen, the dendritic cells are administered back into the patient to induce a potent, cell-mediated anticancer immune response resulting in tumor shrinkage and clinical benefit.

In another experimental approach for the treatment of leukemia, patients? own modified T-cells were infused back into the patients. Prior to this, the T-cells were transduced with a lentivirus to express the CD19-specific chimeric antigen receptor. CD19 is an antigen which is found on B-cell neoplasms, cancerous B-cells, and the lentivirus was the vehicle to transfer the genetic material for CD19 into the cells.? A case report published in the New England Journal of Medicine stated that a patient with chronic lymphocytic leukemia (CLL) was in ongoing remission 10 months after treatment.3

These promising results have spurred continued research for new and safe ways to achieve effective tumor vaccination, and drug developers have explored many cancer immunotherapy strategies. To generate an effective antitumor immunity, therapeutic intervention should drive several functions; specifically, it should promote the antigen presentation functions of dendritic cells, promote the production of protective T-cell responses, stimulate B-cells and overcome immunosuppression characteristics that are common to tumor cells.4

Cell-based therapeutic vaccines are most frequently produced outside the patient?s body and involve isolation of the specific cells, such as dendritic cells, and the introduction of preselected antigens, often with the use of specific vehicle, into the cells. The antigens can be encoded in viral vectors (frequently DNA) or administered as peptides or proteins in a suitable adjuvant and carrier through a long and cumbersome process.

During my doctoral thesis, I conducted immunization experiments using RNA as a negative control, assuming that the RNA would be degraded during the experiment thus making it impossible to use as a vaccine. The physiological role of messenger (m) RNA is to transfer genetic information from the nucleus to the cytoplasm where this information is translated into the corresponding protein. mRNA is known to be very unstable and has a relatively short half-life. But astonishingly, we were able to measure a solid T-cell immune response. We repeated the experiment and confirmed that the RNA we had produced had the potential to be used as a vaccine. Importantly, we didn?t need to isolate the patients? cells: mRNA-based vaccines can be injected directly into the skin (intradermal). The mRNA-based vaccines are then taken up by antigen-presenting cells, such as dendritic cells, and are then able to induce an immune response. Importantly, mRNA-vaccines can also be synthesized quickly for any antigen sequence identified.5

The first mRNA-based vaccines (RNActive?) are now in the clinic for the treatment of prostate cancer and lung cancer and have demonstrated that they do what they are supposed to do ? induce a balanced humoral, as well as T cell-mediated, immune response that is entirely HLA independent. The HLA (human leukocyte antigen) system is used to differentiate the body?s own cells (self) and non-self cells. Additionally, RNA-vaccines do not need a vehicle such as a virus for delivery to the cells, nor do they contain virus-derived elements that are often found in DNA-vaccines. These attributes make RNActive a very safe therapeutic.

The risk of integration of the RNA into the host-genome is minimized (RNA would have been transcribed first to DNA, and then it has to be transported to the nucleus), as is the residual risk of DNA-based vaccines for inactivating or activating genes or affecting cellular regulatory elements, which can induce oncogenesis. Thus, the favorable safety profile of mRNA-based therapies broadens their potential use not only for the treatment of diseases but for use as prophylactic vaccinations. A recent proof-of-concept study using mRNA-based vaccines (RNActive) in animal models for influenza was published in Nature Biotechnology.6

Therapeutic cancer immunotherapies and vaccines have come a long way, and novel, promising approaches give hope for safe and effective treatment options. This may one day lead to the treatment of all cancers as chronic diseases.

Literature

1Kirkwood JM, Butterfield LH, Tarhini AA, Zarour H, Kalinski P, Ferrone S: Immunotherapy of cancer in 2012. CA Cancer J Clin. 2012

2June CH, Blazar BR: T-Cell Infusions: A New Tool for Transfusion Medicine That Has Come of Age. Presentation at 54th ASH Annual Meeting 2013

3Porter DL, Levine BL, Kalos M, Bagg A, and June CH: Chimeric Antigen Receptor?Modified T Cells in Chronic Lymphoid Leukemia. N Engl J Med 2011

4Mellman I, Coukos G, Dranoff G: Cancer immunotherapy comes of age. Nature. 2011

Petsch B, Schnee M, Vogel AB, Lange E, Hoffmann B, Voss D, Schlake T, Thess A, Kallen KJ,

5Hoerr I, Obst R, Rammensee HG, Jung G: In vivo application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies. Eur J Immunol. 2000

6Petsch B, Schnee M, Vogel AB, Lange E, Hoffmann B, Voss D, Schlake T, Thess A, Kallen KJ, Stitz L, Kramps T: Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection. Nat Biotechnol. 2012

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Source: http://rss.sciam.com/click.phdo?i=6e4c8e94da4aa6140a611cdee8e72adc

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Sunday, December 23, 2012

At Length ? Snapshot

?Phoebe Baker Hyde

In 2007, fed up with both external and internal demands to get my appearance right, I cut off my long hair, stopped wearing makeup, packed away most of my jewelry and quit shopping for new clothes or shoes. The following excerpt is taken from Chapter 8 of my memoir, about halfway through the year-long experiment.

My aunt, a committed practitioner of Zen Buddhism, sent me a book that fall as I struggled with a new discomfort: plainness was liberating but hadn?t given me perfect inner peace about my relationships or roles in the world. The story of my experiment wasn?t moving briskly toward some happy ending. The book was by a woman who had been a member of a Zen monastery and then become a first-time parent in her forties. I didn?t feel I had much use for this personal growth/self-help book, yet I read it the way one drinks blue Gatorade after thirty-six hours of food poisoning?my cherished personal objections becoming irrelevant in the deliciousness of its functionality.

As I read the book, I was reminded that in graduate school, I?d relied on a semiregular meditation practice to dull the sting of days when I understood myself to be an admissions mistake. And so one night I got out a candle and the brass singing bowl I picked up in Vietnam. I sat cross-legged in our bedroom window seat with my back straight, a zafulike pillow tucked under my butt, my eyes unfocused at a vague spot six inches away from my knees, and my hands in the meditation mudra, the shape of infinity and openness.

After forty-five seconds, my jaw went slack, and I fell asleep. I jerked myself awake, assumed my position with much more resolve, and promptly fell asleep again. I blew out the candle, got into bed, and stayed up late reading?sullenly?about how much meditation can help people at wit?s end.

The next night I caffeinated myself. I didn?t nod off and did manage to count my breaths past six, but instead of calm, I got more chatter about my problems, courtesy of the Voice.

I can?t believe your OB didn?t give you a postpartum-depression screen. Hello! This is not the fifties!

Innnnnnn and Ouuuut. Breath one and breath two.

I mean you got some of the best medical care available in Asia! What about all those women having babies over on the Mainland or in Vietnam? What do you think is going unnoticed or unchecked or crappily stitched up in them?

I pretended not to be interested.

You fucking should be interested! Why is it that you think of motherhood as a path to personal fulfillment instead of a basic human chore? Who told you labor and childbirth were an opportunity for self-expression? And if you?re looking for inner peace and happiness, then why are you being such a hard-assed drill sergeant about everything? You want to be self-disciplined about your work, self-disciplined about health and exercise, self-disciplined about not using plastic bags and buying organic?and now, on top of it all, you have to be disciplined about beauty? You?ve given up pretty hair so you can obsess about a pretty MIND?

Yes.

Come on! It?s really hard to be woman, and it?s really hard to be you!

I didn?t listen to whiners. These thoughts were simply clouds passing through my mind.

They ain?t passing, sister. I got a six-month supply of unused estrogen right here telling me to sit tight.

I gave up on the meditation. Whatever she was fueled by right now, the Voice of complaint was just too loud to contend with or wait out. And while she was annoying, accusatory, and defensive all at once, I felt she had valid points, maybe even all valid points. Harping on them, however, solved nothing and gave me no peace.

?Your life is a garden,? the Zen parenting book said. ?And you are the only gardener.? Maybe this was so, but during the year of my experiment, I just couldn?t see it that way. I felt the garden was elsewhere, out on the Morning Path, hidden deep inside the vegetative awareness of the banyan trees, or located somewhere in the future when all the problems of all the world?s women (starting with my own) were solved. I insisted?and the Voice in my head backed me up 100 percent?that my problems lay with John?s job, my weakness for skin-care products, the expatriate lifestyle, an archaic medical establishment ignorant of female experience, a sensitive and sleepless kid, and the last hundred pages of my novel. And the solution to all these problems was the story I told myself about beauty?both inner and outer. I believed it was something out there, and attainable, if only I could improve myself enough to gain its blessing. I was very attached to this beauty story because I thought it was all I had.

*

On a brilliant, cool morning in late October, John and I drive the kids out to Concord for a walk around Walden Pond. On the banks of this pond, Henry David Thoreau threw off the bonds of civilization and took to the woods ?to live deliberately?and not, when [he] came to die, discover that [he] had not lived.? I?m excited to see the small, self-made cabin, even if it?s only a reproduction, but when we arrive, the adjacent parking lot is jammed with cars. I fret, but John stays cool and we find a spot. We head around the pond on a woodsy, unpaved path, and as the stroller hits gnarled roots, I wince. Five years and two kids have turned my scorn for ?overcivilized? hiking into appreciation for sidewalks.

We make slow, bumpy progress, stopping occasionally to throw stones in. Fringed by scarlet leaves, the bright, still pond looks beautiful to me. But I?m also aware that today, each of us is projecting our own story upon its emerald surface: the story of easy parking and literary sightseeing (me), the story of an athletic warm-up to hearty fall lunch (John), and the story of innocence and an unjust reprimand (Hattie, who gets yelled at after nearly pushing John in). Orson, at two and a half, is the only one of us who meets Walden Pond where it lives: in its wetness and splashiness. Halfway around, even he comes up with a pond story that has to be curtailed?the story of a wild forest boy swinging a pointed stick near people?s eyes. Our stories delight us intensely, yet often fail us, or come to an end.

I saw straight through my own beauty story very briefly, in the fall of 2010. Orson was already a year and a half old. Like anyone going up to bat a second time, I?d invented some inspiring motivational tales about how things would go in my second child?s babyhood: better sleep habits, better mealtimes, better attitude, better everything. Eighteen months in, my inner sales pitches were failing me, and the chaos was still expanding like a mushroom cloud. From experience I knew meditation was beyond me as a sleep-deprived baby mama, so I turned to a book of Zen koans instead.

The idea of a koan is that you run a piece of verbal nonsense through your head until sense and nonsense trade places and offer up insight. For all of us who like to butt our heads against something, the answerless riddle of a koan is an ideal wall. The bonus is that no staying awake on a soft cushion in a quiet room is required. You can work on a koan while pushing a swing or washing a dish.

The koan I began with was this:

Does a dog have Buddha nature?

No.

I started repeating this Q&A in my mind while I diapered, folded laundry, and shopped for chicken breast. After a week or so of unproductive repetition, I started thinking that ?Buddha nature? was pretty much equivalent to ?inner beauty,? and so I subbed in those words, instead.

Does a dog have inner beauty?

No.

Is a dog beautiful?

No.

I was dismayed by how negative this riddle solving was, and how cruel. Why was ?No? kicking the poor dog? Frustrated by my lack of progress, I tried switching the subject around, too, so that I became the dog.

When I tried to stay patient with the kids, was that inner beauty?

No.

When I bought used snowpants to economize was that Buddha nature?

No.

Sometimes I couldn?t believe how hard ?No? was riding my ass. How could it be that even with my very best efforts at being an attentive mom and wife?at staying in the game professionally, at vanquishing the yardwork and paperwork, at sending the relatives pictures of the kids in a timely fashion, and not freaking out at my husband when he couldn?t figure out where he was going to move us to next?the answer was still No? My writing? No. My education? No. My hopes, even for health and love and peace in the world? No. No. No. Not beautiful. Not Buddha nature. I decided that koans were for masochists and people with better senses of self-worth than I. I told No to go to hell, but it kept running through my mind like a spiritually nasty pop song, endlessly repeating its downer mantra.

My fight with No ended one cold fall morning as I took Orson for a walk to Kelley Pond. This small, man-made runoff basin was hidden in the woods behind a nearby elementary school. It was a convenient nature walk, if imperfect: I didn?t like to pass the muddy town mulch area to get there, and the woods were not thick enough to hide the plastic toys in people?s backyards. That day, though, the water in the pond was bright and clear, and the surrounding trees were decked out in autumnal finery. I looked at the long grass tilting at the bank, still a summer green. Orson stared quietly at the yellow, red, and brown trees and mirrorlike water, rapt.

Is this pond beautiful?

Does it have Buddha nature?

No.

If this pond isn?t beautiful, my brain screamed at the koan, then nothing is!

With that, the word beauty dissolved. It cleared to the edges of my understanding like grease moving away from a drop of soap. And in the clean, empty center that remained were just the plain things themselves: the water in the pond, the deleafing trees, the breeze carrying vapors of pine and compost, the bright dots of sun on the toes of Orson?s boots. I looked from the pond to a pile of discarded beer cans in the undergrowth and found I had no feelings of comparison or preference for either one. I didn?t wish the traffic noise away; it was okay with me. I looked down at my hands too?dry, cold, and veined, resting on the stroller?s handles. The knuckles were raw, and palest pink. The realness of my hands surprised me, as did the pulse I could feel inside.

That moment of realization was a powerful shock?my brain would always draw me to what it knew as beautiful and would always give those things special value, but that brain itself was acculturated, hormonal, self-referential, and hardwired in certain limiting ways. It was deeply marvelous to draw my own mental software aside like a curtain?even for an instant?and peek at a whole universe unbound by my classifications, judgments, language, or beloved stories.

We do live in a world filled with these stories: success stories, love stories, stories of redemption and failure. The good ones can help us grow, or point us in the right direction. In the years since my experiment, I?ve worked on creating a new story of beauty for myself?one inspired by the rings of a banyan tree, with the gift of life at the core, and the delight of art and artifice at the outermost edge. But even a good story can set us up to hold reality at gunpoint, waiting for the promised payoff: I need youth or a semblance of it! the Voice rails. I need happiness or self-worth or inner peace! I need my life to be better than it is, and I will do whatever it takes to make it that way?just give me the ten-step program! But just as caffeine doesn?t solve a chronic sleep debt, stories of ambitious self-improvement don?t address the reality of a chaotic and imperfect world. Sometimes the gardens of our lives become stroller-unfriendly jungles filled with pet-snatching Burmese pythons. And what then? Raze the forest and unroll the Astroturf?

The more effective approach, I?m beginning to see, it to embrace the paradise that is already here: my real, living body; my real children; and my real husband. All of us are more deserving of my best effort than the phantoms of perfection: the woman I feel I should be, the husband I sometimes wish I had, the children I hope I am raising.

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Phoebe Baker Hyde?s fiction and essays have been published in High Plains Literary Review, Confrontation, Chrysalis, the online travel journal Pology, and The Los Angeles Times Magazine. Her forthcoming memoir, The Beauty Experiment, takes place in Hong Kong, but she currently lives in Boston.

Photo by Harriet Liang.

Source: http://atlengthmag.com/prose/snapshot/

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Frugal Family Tree: Don't Let a Greedy Grinch Ruin Your Holidays

Frugal Family Tree: Don't Let a Greedy Grinch Ruin Your Holidays

Don't Let a Greedy Grinch Ruin Your Holidays


Over the years I have heard many stories of greedy?Grinch?trying to steal someones Christmas. It makes me so sad! Well we can all?thwart?the?Grinch?with being aware of our own home security. We all get busy in the rush of holiday shopping, friends and family visiting and taking road trips. A few simple but often?forgettable?things can help decrease your odds of Grinch deciding your home will be his next target.

Remembering to lock doors and windows before you go out shopping, even if its for a quick trip to the store. Leaving a light on while your out to let it appear someone is there. Turn off your Christmas tree lights and be sure to close the blinds. Open blinds letting your Christmas tree be seen is beautiful but also a lure to a greedy Grinch.?

Leaving the porch light on is another small but sometimes?forgettable?thing that can help keep your home less of a target. Having motion activated exterior lights is also a good idea. If you are planning to go on a trip have your neighbors gather your mail and newspaper. Don't forget to lock the doors that lead to your home from the garage. I often have forgotten that one myself. A garage can be easier to get into and if your home door is lock often the Grinch can't get further than your garage.?

In the delight of the Holiday season just be sure to be take a few extra steps to make sure you have a bit more home?security.

Here is a cute?article about how Santa can perhaps be the slickest break in artist of them all! (but we?don't?mind?him, he leaves presents in exchange for cookies and milk!)

Santa Claus: Holiday's Biggest Ho-Ho-Home Security Threat


*This is a sponsored post

Source: http://www.frugalfamilytree.com/2012/12/dont-let-greedy-grinch-ruin-your.html

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Tricks Of The Commercial Real Estate Trade | NASDAQ Stock ...

Although industrial and commercial properties are constantly appearing on the market, they don?t get preferential market listings the same way regular homes do. The advice presented in the following article will enlighten you on how to find your way through the real estate market to locate these industrial and commercial properties.

Advertising your property to parties locally and abroad is important to ensure you get the best price possible. There are a lot of people who make the big mistake who think that only local people want to purchase their property. Many investors will consider purchasing a property outside their own region if the price is right.

Consider any tax deductions you might get from your commercial real estate investment. Investors will receive tax breaks for both interest and depreciation of property. Sometimes an investor will get a bit of money that is taxed even though it is not received. It is important that you become familiar with this particular kind of income before you make any investments.

You have to purchase a real estate appraisal yourself before you can qualify for a commercial loan. If someone else orders an appraisal for you, the bank may not accept that appraisal. Be properly prepared by ordering the appraisal directly.

Ask your broker to explain the methods he uses to negotiate deals before hiring him. Much like you would interview a prospective employee, question their experience and training. In addition, you should ensure that the methods they employ are ethical and that they know how to go about obtaining the best deals. Ask them to tell you about their past work, including their successes and mistakes.

Be sure to enlist the assistance of an excellent real estate attorney to review any contracts or financing documents for your commercial properties. If something is amiss with your endeavors, you need a great person to clear your name of threats.

You may need to make some changes to the commercial space you just rented before moving in. These changes could simply be cosmetic ones as simple as a new coat of paint or moving the furniture around. Normally, however, it may be something a little more involved like walls being moved. Negotiate payment for these improvements ahead of time, and attempt to have the landlord pay at least part of the costs.

Collect all of your financial paperwork, including bank statements and proof of income, before you begin searching for a property. If you don?t have these, banks won?t know how you manage your money, which might cause them not to lend the amount of money that you need.

One counterintuitive fact about the apartment market is that many experts recommend avoiding properties with fewer than ten units, as they are actually more of a pain to deal with than large complexes. Of course, every property is different, so you should rely more on your research to make the appropriate decision.

Before making a real estate purchase, sit down and talk with your tax adviser. A tax expert can advise you on how much the property costs and what amount of your real estate income will be taxable. Try to find a location that does not have high taxes, you can consult with an adviser for more information.

Consider using the principals of feng shui in the interior design of your commercial investment properties. If you provide a lot of open space in your units and avoid clutter as much as possible, buyers are more likely to be interested in your property.

Consider what youR actual goals are before you begin to invest in commercial real estate. Write down everything you need in a commercial property, such as number of conference rooms, offices, restrooms and how much square footage.

There are many thing that need to be taken into consideration when purchasing a piece of commercial property, location is just the beginning. When you have the information you need, decisions are much easier to make.

Do you think that take a look at the site here is something that is confusing? Join the club. Luckily, the article above has taken much of the guesswork out of the subject. Keep this article close in case you need to reread it. This will help you stay on the correct path.

Source: http://thenasdaqstockexchange.com/2012/12/22/tricks-of-the-commercial-real-estate-trade/

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Congress completes $633B defense bill

WASHINGTON (AP) ? Congress sent President Barack Obama a $633 billion defense bill for next year that would tighten penalties on Iran to thwart its nuclear ambitions and bulk up security at diplomatic missions worldwide after the deadly Sept. 11 raid in Libya.

The Senate voted 81-14 on Friday for the massive policy measure that covers the cost of ships, aircraft, weapons and military personnel. The vote came less than 24 hours after the House passed the bill, 315-107.

The White House has threatened a veto, but it remains unclear whether President Barack Obama will reject the solidly bipartisan legislation. The bill passed by veto-proof margins.

The vote came against the backdrop of looming reductions in projected military spending driven by the automatic, across-the-board cuts that will take place if the "fiscal cliff" negotiations fail. The Pentagon faces cuts of $55 billion after the first of the year that Defense Secretary Leon Panetta has warned would be devastating to the services.

Even if that is averted, the bill approved Friday reflects cuts in defense dollars that Obama and congressional Republicans agreed to in August 2011 as well as the end to the war in Iraq and the drawdown of U.S. forces in Afghanistan. The bill would authorize $528 billion for the Defense Department's base budget, $17 billion for defense and nuclear programs in the Energy Department and $88.5 billion for the war in Afghanistan.

The bill is about $29 billion less than the current level, largely due to smaller amounts for Iraq and Afghanistan.

In a speech this week, Panetta complained that lawmakers spared weapons that he had wanted to retire and steered money to other programs. The bill, which is $1.7 billion more than Obama requested, saves a version of the Global Hawk unmanned aircraft, includes upgrades for tanks and money for armored vehicles.

"Aircraft, ships, tanks, bases, even those that have outlived their usefulness, have a natural political constituency," Panetta said. "Readiness does not."

"What's more, readiness is too often sacrificed in favor of a larger and less effective force. I am determined to avoid that outcome."

Panetta said members of the House and Senate "diverted about $74 billion of what we asked for in savings in our proposed budget to the Congress, and they diverted them to other areas that, frankly, we don't need."

The bill responds to new threats and upheaval around the globe while still providing billions for the decade-plus war in Afghanistan. The measure presses the military on possible options to end the bloodshed in Syria.

The final measure, a product of negotiations between the House and Senate, addresses several concerns raised by the Obama administration. It would eliminate restrictions on alternative fuels that the White House had complained about and jettison limits on the administration's ability to implement a nuclear weapons reduction treaty.

The bill would limit the president's authority to transfer terrorist suspects from the military prison at Guantanamo Bay, Cuba, for one year ? a provision similar to current law. That had drawn complaints from the White House.

Election-year politics and changes in society shaped the final measure.

As suicides among active-duty soldiers have accelerated, the bill would allow a commander officer or health profession to ask if a member of the services owns a firearm if they consider the individual at risk for either suicide or hurting others.

Negotiators kept a Senate-passed provision sponsored by Sen. Jeanne Shaheen, D-N.H., that expands health insurance coverage for military women and their dependents who decide to have abortions in cases of rape and incest.

Previously, health coverage applied only to abortions in cases where the life of the mother was endangered.

Democrats argued throughout the election year that Republicans were waging a "war on women" over contraception and abortion, a charge the GOP denied. Democrats and Obama held a clear edge with female voters in the election and some Republicans are reappraising their approach to issues important to women.

Negotiators jettisoned a House provision that would have banned gay marriage on military installations, weeks after the chapel at the U.S. Military Academy at West Point held its first same-sex marriage. A senior Army chaplain conducted the ceremony. The bill does have a conscience clause for chaplains.

The measure includes a 1.7 percent pay raise for military personnel.

The legislated sanctions would hit Iran's energy, shipping and shipbuilding sectors as well as Iran's ports, blacklisting them as "entities of proliferation concern." The bill would impose penalties on anyone caught supplying precious metals to Iran, and sanctions on Iranian broadcasting.

The bill eliminated a House provision barring the military from buying alternative fuels if the cost exceeds traditional fossil fuels, a measure that had drawn a veto threat. Instead, negotiators said the Pentagon could do so as long as the Energy and Agriculture departments make their financial contributions to the work.

The bill also watered down a House effort to require construction of an East Coast missile defense site, instead pressing the Pentagon to study three possible locations.

Months after the attack on the U.S. Consulate in Benghazi, Libya, that killed Ambassador Chris Stevens and three other Americans, the bill would provide an additional 1,000 Marines for embassy security.

Reacting to relentless violence in Syria, the bill would require the Pentagon to report to Congress on possible military options.

The bill would authorize nearly $480 million for U.S.-Israeli missile defense, including $211 million for Iron Dome, the system designed to intercept short-range rockets and mortars fired by Palestinian militants from Gaza at southern Israel.

The agreement retained a Senate provision that stops the Pentagon from sending additional spies overseas until Congress has answers about the cost and how the spies would be used.

Source: http://news.yahoo.com/congress-completes-633b-defense-bill-203351297.html

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